Distinct Brca1 mutations differentially reduce hematopoietic stem cell function. Mus musculus
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA356889
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资源简介：
Mgbemena et al report that hematopoietic stem cells have an absolute requirement for Brca1 to survive. They also show that humanization of the mouse Brca1 e with a knocked-in BRCA1 cDNA, but not a mutant BRCA1/5382insC cDNA, fully substitutes for the mouse Brca1 during both embryonic development and hematopoiesis. Overall design: Enlarged spleens from 2-3 mo. old Brca1∆/∆ mice and Brca1+/+ mice were taken for RNA extraction and processed for paired-end RNA seq.
创建时间：
2016-12-09
