IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]

Two isoforms of adenylosuccinate synthetase, ADSS and ADSSL1, catalyze the reaction of IMP, aspartate, and GTP to form adenylosuccinate, GDP, and orthophosphate (Powell et al. 1992; Sun et al. 2005). ADSS is a homotetramer (unpublished crystallographic data - PDB 2V40) and ADSSL1 is inferred to be a tetramer likewise.

两种腺苷琥珀酸合酶异构体，ADSS及ADSSL1，催化肌苷酸、天冬氨酸和鸟苷三磷酸反应，生成腺苷琥珀酸、鸟苷二磷酸和正磷酸（Powell等，1992；Sun等，2005）。ADSS为同源四聚体（未发表晶体学数据 - PDB 2V40），而ADSSL1据推测亦为四聚体结构。