SNP array analysis has facilitated the identification of novel chromosomal alterations associated with disease and SNPs related to Adverse Drug Reactions in neuroblastoma

Chromosome abnormalities are common characteristics of neuroblastoma and have been associated with treatment, relapse and survival risk factors. The processes governing the incidence or advancement of chromosomal copy number abnormalities remain unclear, despite progress in understanding their prognostic implications. Single nucleotide polymorphism (SNP) array analysis was performed on a set of 45 neuroblastoma samples in order to examine chromosomal CNAs and SNPs. The present study aimed to provide a comprehensive understanding of genetic alterations, clinical implications, and the association between copy number aberrations (CNAs) and clinical parameters. 45 neuroblastoma samples were analyzed with Infinium CytoSNP-850K v1.2 BeadChip SNP arrays.