Investigation of the interrelationship between SLC26A4 and SLC26A7 in iodide transport.. Mus musculus

Both SLC26A7 and SLC26A4 are important transporters involved in iodide transport on the lumenal side of thyroid follicular cells. However, how these molecules interact and how they share their roles is still poorly understood. In this project, we extracted RNA from the thyroid glands of Slc26a7KO and Slc26a4KO mice and wild-type mice, and compared their expression variations by RNA-seq in order to clarify their interrelationship. In addition, we evaluated the expression levels of iodide transporters in the thyroid gland of wild-type mice with the secondary objective of identifying key factors of iodide transport.