Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 25 round 7

NIAID Data Ecosystem2026-05-01 收录

蛋白质定向进化

计算酶设计

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Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 25 round 7

创建时间：

2023-10-04

Kinetic Characterization of 100 Glycoside Hydrolase Mutants Enables the Discovery of Structural Features Correlated with Kinetic Constants

酶动力学表征

计算酶设计

The use of computational modeling algorithms to guide the design of novel enzyme catalysts is a rapidly growing field. Force-field based methods have now been used to engineer both enzyme specificity

Figshare2016-02-23 更新30

Crystal Structure of Kemp Eliminase HG3.14 in unbound state, 277K

蛋白质晶体学

计算酶设计

Crystal Structure of Kemp Eliminase HG3.14 in unbound state, 277K Descriptor: Kemp Eliminase HG3, SULFATE ION Authors: Broom, A, Rakotoharisoa, R.V, Thompson, M.C, Fraser, J.S, Chica, R.A. Deposit dat

Protein Data Bank Japan2024-03-06 更新20

Table1_Binding pocket stabilization by high-throughput screening of yeast display libraries.DOCX

蛋白质定向进化

高通量药物筛选

Protein dynamics have a great influence on the binding pockets of some therapeutic targets. Flexible protein binding sites can result in transient binding pocket formation which might have a negative

NIAID Data Ecosystem10

Amino acid diversity encoded in second generation library.

蛋白质定向进化

合成生物文库设计

CDR’ refers to a degenerate codon with the following nucleotide frequencies: 20% A, 15% C, 25% G, and 40% T at site 1, 50% A, 25% C, 15% G, and 10% T at site 2, and 0% A, 45% C, 10% G, and 45% T at si

NIAID Data Ecosystem30

Structure-augmented MLDE

蛋白质定向进化

结构增强机器学习

Supplementary Files for Structure-augmented MLDE for GB1

Zenodo2024-02-27 更新20