首页/数据集/TBX20 Consolidates Cardiac Reprogramming Factors to Enhance Contractility and Energy Metabolism in Human Induced Cardiomyocytes. TBX20 Consolidates Cardiac Reprogramming Factors to Enhance Contractility and Energy Metabolism in Human Induced Cardiomyocytes

TBX20 Consolidates Cardiac Reprogramming Factors to Enhance Contractility and Energy Metabolism in Human Induced Cardiomyocytes. TBX20 Consolidates Cardiac Reprogramming Factors to Enhance Contractility and Energy Metabolism in Human Induced Cardiomyocytes

NIAID Data Ecosystem2026-03-13 收录

心脏重编程

心肌细胞代谢

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA798380 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2022-01-17

心肌细胞代谢

镁缺乏效应

Rats (8 weeks old) were fed the control diet or the Mg-deficient diet for 4–6 weeks, and [Mg2+]i was measured with the fluorescent indicator furaptra in the myocytes isolated from control rats (Contro

NIAID Data Ecosystem60

Cardiac reprogramming and Gata4 overexpression reduce fibrosis and improve diastolic dysfunction in heart failure with preserved ejection fraction [Visium]. Cardiac reprogramming and Gata4 overexpression reduce fibrosis and improve diastolic dysfunction in heart failure with preserved ejection fraction [Visium]

心脏重编程

空间转录组学

Fibrosis is important pathogenesis in heart failure with preserved ejection fraction (HFpEF). We previously reported that the overexpression of cardiac transcription factors, Mef2c/Gata4/Tbx5/Hand2 (M

NIAID Data Ecosystem40

Cardiomyocyte Pdk4 response is associated with metabolic maladaptation in aging

心肌细胞代谢

衰老相关代谢

Pyruvate Dehydrogenase Kinase 4 (Pdk4) is a pyruvate dehydrogenase inhibiton gene that strongly regulates metabolism. We studied the expression of Pdk4 in the young and aged mouse heart in both health

NIAID Data Ecosystem30

Transcriptomic analysis reveals a statin-induced core molecular signature in human iPSC-CMs. Transcriptomic analysis reveals a statin-induced core molecular signature in human iPSC-CMs

心肌细胞代谢

药物转录组学

Statins prevent cardiovascular disease via their salutary function as inhibitors of cholesterol biosynthesis and mediators of pleiotropic effects on the cardiovascular system. The current study focuse

NIAID Data Ecosystem40

Engineering effector domains of MEF2C and GATA4 enhances cardiac reprogramming

心脏重编程

转录因子效应域工程

The transcription factors MEF2C, GATA4, and TBX5 (MGT) are well established for converting fibroblasts into induced cardiomyocytes (iCMs). However, these reprogramming factors contain effector domains

NIAID Data Ecosystem40

TBX20 Consolidates Cardiac Reprogramming Factors to Enhance Contractility and Energy Metabolism in Human Induced Cardiomyocytes. TBX20 Consolidates Cardiac Reprogramming Factors to Enhance Contractility and Energy Metabolism in Human Induced Cardiomyocytes

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