Structure of FACTOR VIIA in complex with the inhibitor BMS-593214 also known as 2'-[(6R,6AR,11BR)-2-CARBAMIMIDOYL-6,6A,7,11B-TETRAHYDRO-5H-INDENO[2,1-C]QUINOLIN-6-YL]-5'-HYDROXY-4'-METHOXYBIPHENYL-4-CARBOXYLIC ACID

Structure of FACTOR VIIA in complex with the inhibitor BMS-593214 also known as 2'-[(6R,6AR,11BR)-2-CARBAMIMIDOYL-6,6A,7,11B-TETRAHYDRO-5H-INDENO[2,1-C]QUINOLIN-6-YL]-5'-HYDROXY-4'-METHOXYBIPHENYL-4-CARBOXYLIC ACID Descriptor: 2'-[(6R,6aR,11bR)-2-carbamimidoyl-6,6a,7,11b-tetrahydro-5H-indeno[2,1-c]quinolin-6-yl]-5'-hydroxy-4'-methoxybiphenyl-4-carboxylic acid, CALCIUM ION, Factor VII heavy chain, ... Authors: Wei, A. Deposit date: 2013-01-16 Release date: 2013-03-20 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor. Bioorg.Med.Chem.Lett., 23, 2013

与抑制剂BMS-593214（又名2'-[(6R,6aR,11bR)-2-脒基-6,6a,7,11b-四氢-5H-茚并[2,1-c]喹啉-6-基]-5'-羟基-4'-甲氧基联苯-4-羧酸）结合的凝血因子VIIa的结构。描述物：2'-[(6R,6aR,11bR)-2-脒基-6,6a,7,11b-四氢-5H-茚并[2,1-c]喹啉-6-基]-5'-羟基-4'-甲氧基联苯-4-羧酸、钙离子、凝血因子VII重链……作者：Wei, A.。提交日期：2013-01-16；发布日期：2013-03-20；最后修改日期：2024-10-09。实验方法：X射线衍射（分辨率1.82 Å）。引用文献：《BMS-593214：一种强效选择性FVIIa抑制剂的发现与克级合成》，《Bioorg.Med.Chem.Lett.》，2013年，第23卷。