Crystal structure of Saporin-L1 in complex with the cyclic tetranucleotide inhibitor, a transition state analogue

Crystal structure of Saporin-L1 in complex with the cyclic tetranucleotide inhibitor, a transition state analogue Descriptor: 9,9'-{(2R,3R,3aR,5S,7aR,9R,10R,10aR,12S,23R,25aR,27R,28R,28aR,30S,32aR,35aR,37S,39aR)-9-(6-amino-9H-purin-9-yl)-34-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-5,12,23,30,37-pentahydroxy-3,10,28-trimethoxy-5,12,23,30,37-pentaoxidotetracosahydro-2H,7H,25H-trifuro[3,2-f:3',2'-l:3'',2''-x]pyrrolo[3,4-r][1,3,5,9,11,15,17,21,23,27,29,2,4,10,16,22,28]undecaoxazapentaphosphacyclopentatriacontine-2,27-diyl}bis(2-amino-3,9-dihydro-6H-purin-6-one), Vacuolar saporin Authors: Ho, M, Sturm, M.B, Almo, S.C, Schramm, V.L. Deposit date: 2009-05-20 Release date: 2009-12-08 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proc.Natl.Acad.Sci.USA, 106, 2009

Saporin-L1与环状四核苷酸抑制剂（过渡态类似物，transition state analogue）结合的晶体结构
描述物：9,9'-{(2R,3R,3aR,5S,7aR,9R,10R,10aR,12S,23R,25aR,27R,28R,28aR,30S,32aR,35aR,37S,39aR)-9-(6-氨基-9H-嘌呤-9-基)-34-[(4-氨基-5H-吡咯并[3,2-d]嘧啶-7-基)甲基]-5,12,23,30,37-五羟基-3,10,28-三甲氧基-5,12,23,30,37-五氧代二十四氢-2H,7H,25H-三呋喃并[3,2-f:3',2'-l:3'',2''-x]吡咯并[3,4-r][1,3,5,9,11,15,17,21,23,27,29,2,4,10,16,22,28]十一氧杂氮杂五环三十五碳烷-2,27-二基}双(2-氨基-3,9-二氢-6H-嘌呤-6-酮)，液泡皂草素
作者：Ho, M、Sturm, M.B、Almo, S.C、Schramm, V.L.
存入日期：2009-05-20
发布日期：2009-12-08
末次修改日期：2024-02-21
实验方法：X射线衍射（X-RAY DIFFRACTION，1.8埃）
引用文献：《蓖麻毒素与Saporin类核糖体失活蛋白（ribosome-inactivating proteins）结构中的过渡态类似物》，《美国国家科学院院刊》（Proc.Natl.Acad.Sci.USA），第106卷，2009年