Metabolic stability of compounds 29, 30 and 48 and reference compounds against rat liver microsomesa.
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a0.225 mg/mL protein, NADP+-regenerating system, [inhibitor]: 0.5 µM, incubation at 37°C, samples taken at 0, 15, 30, and 60, 90 min, determination of parent compound by MS.bClblood: estimated blood clearance in rats as calculated based on in vitro intrinsic clearance. The values are representative for two independent experiments that essentially gave the same results.
创建时间：
2015-12-02
