Confirmation and secondary assays for “hit” antagonists of AaDOP2 and human D1 receptor.
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Select chemistries and the assay control (SCH23390) were tested in dose-response cAMP assays in the presence of 3 µM dopamine in AaDOP2- or 100 nM dopamine in hD1-expressing cells (Figure 5). Compounds with IC50 values ≥10 µM are considered to lack activity at AaDOP2 and were not tested at hD1. N.D. = not determined; hD1 = Human D1 dopamine receptor.
创建时间：
2015-12-02
