Crystallographic structure of AcrB V612F with bound minocycline

Crystallographic structure of AcrB V612F with bound minocycline Descriptor: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, DARPIN, Multidrug efflux pump subunit AcrB Authors: Lazarova, M, Diederichs, K, Pos, K.M. Deposit date: 2024-05-27 Release date: 2025-06-11 Last modified: 2026-01-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Conformational plasticity across phylogenetic clusters of RND multidrug efflux pumps and its impact on substrate specificity. Nat Commun, 16, 2025