Spontaneous Direct Current (DC) modulated activity in in vitro ferret slices

Transcranial direct current stimulation (tDCS) is a technique extensively used in the clinical realm to modulate cortical activity. tDCS has been suggested, among other applications, to induce suppression of epileptiform activity. However, the understanding of the mechanisms underlying tDCS neuromodulation is still limited. The goal of the present study was to explore whether DC stimulation has the potential to modulate cortical activity in vitro. We applied exogenous constant electric fields (EF) with different polarities and intensities to in vitro ferret cortical slices expressing slow oscillatory activity. The present model might be useful to better understand the neuromodulation mechanisms of tDCS in the clinical realm. The dataset contains data for three different subjects. Two of these subjects have two sessions (2 different slices) and the other just one slice.