Burden test for KANL and ADSP unrelated datasets.

Collapsing and combine (CMC) test of rare variants by Fisher's exact test for (i) variants with a MAF≤1% and categorized to have a high or moderated effect (MAF≤1% HM) and (ii) singleton variants categorized to have a high or moderated effect (AC1 HM), for the unrelated datasets analyzed in this study (unrelated KANL and Sporadic ADSP). Number of polymorphic variants (N), odds ratio (OR) and two sided pvalue (P) are given. Enriched genes with nominally significant pvalues are bold highlighted.