Tandem Synthesis of 3‑Chloro-4-iodoisoxazoles from 1‑Copper(I) Alkynes, Dichloroformaldoxime, and Molecular Iodine

A tandem synthesis
for structurally novel 3-chloro-4-iodoisoxazoles
was developed by simply mixing 1-copper­(I) alkynes, dichloro­formaldoxime,
and molecular iodine together. The combination of 1-copper­(I) alkyne
and molecular iodine was well used as a synthetic equivalent of 1-iodoalkyne
without the need for tedious preparation, purification, and storage
of 1-iodoalkyne.

一种针对结构新颖的3-氯-4-碘代异唑的串联合成法得以开发，该方法仅需将一价铜烷烃、二氯甲酰脒以及分子碘简单混合即可。一价铜烷烃与分子碘的结合被广泛用作1-碘代烷烃的合成替代品，无需繁琐的制备、纯化和储存过程。