tRNA-guanine Transglycosylase (TGT) in co-crystallized complex with 6-amino-2-(methylamino)-4-(4-(trifluoromethyl)phenethyl)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one

tRNA-guanine Transglycosylase (TGT) in co-crystallized complex with 6-amino-2-(methylamino)-4-(4-(trifluoromethyl)phenethyl)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one Descriptor: 6-amino-2-(methylamino)-4-(4-(trifluoromethyl)phenethyl)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ... Authors: Nguyen, A, Heine, A, Klebe, G. Deposit date: 2020-03-27 Release date: 2020-04-08 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Co-crystallization and 19F NMR reveal dimer disturbing inhibitors and conformational changes at dimer contacts To Be Published

本数据集对应与6-氨基-2-(甲氨基)-4-(4-(三氟甲基)苯乙基)-3,7-二氢-8H-咪唑并[4,5-g]喹唑啉-8-酮共结晶形成复合物的tRNA-鸟嘌呤转糖基酶（tRNA-guanine Transglycosylase, TGT）。数据集描述项包括：6-氨基-2-(甲氨基)-4-(4-(三氟甲基)苯乙基)-3,7-二氢-8H-咪唑并[4,5-g]喹唑啉-8-酮、甘油（GLYCEROL）、Q碱基tRNA-核糖基转移酶（Queuine tRNA-ribosyltransferase）…… 作者：Nguyen, A、Heine, A、Klebe, G。存入日期：2020-03-27；发布日期：2020-04-08；最后修改日期：2024-01-24。实验方法：X射线衍射（分辨率1.4 Å）。引用文献：《共结晶与19F核磁共振揭示干扰二聚体的抑制剂及二聚体接触界面的构象变化》，待发表。