Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P221

Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P221 Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETIC ACID, ... Authors: Maltseva, N, Kim, Y, Mulligan, R, Makowska-Grzyska, M, Gu, M, Gollapalli, D.R, Hedstrom, L, Joachimiak, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2017-02-26 Release date: 2017-03-22 Last modified: 2026-03-25 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Role of the Mobile Active Site Flap in IMP Dehydrogenase Inhibitor Binding. Acs Infect Dis., 11, 2025

产气荚膜梭菌（Clostridium perfringens）来源的肌苷5'-单磷酸脱氢酶（Inosine 5'-monophosphate Dehydrogenase）与肌苷单磷酸（IMP）及P221形成的复合物晶体结构，配体描述：(4R)-2-甲基戊烷-2,4-二醇、(4S)-2-甲基-2,4-戊二醇、乙酸等。作者：Maltseva N、Kim Y、Mulligan R、Makowska-Grzyska M、Gu M、Gollapalli D.R.、Hedstrom L、Joachimiak A、Anderson W.F.，以及传染病结构基因组学中心（Center for Structural Genomics of Infectious Diseases, CSGID）。存档日期：2017-02-26；发布日期：2017-03-22；最后修改日期：2026-03-25。解析方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.85埃（Å）。引用文献：《活性位点柔性扣盖在肌苷单磷酸脱氢酶抑制剂结合中的作用》，发表于《ACS传染病杂志（ACS Infect Dis.）》2025年第11卷。