Outcomes of patient admitted to critical care unit with vs without inferior vena cava collapsibility and distensibility assessment. (IVCIN TRIAL)

Title: Outcomes of patient admitted to critical care unit with vs without inferior vena cava collapsibility and distensibility assessment. (IVCIN TRIAL)
This dataset originates from a randomized controlled trial comparing fluid management strategies in critically ill patients using either clinical parameters or ultrasound-guided Inferior Vena Cava Collapsibility/Distensibility Index (IVC CI/DI). After informed consent, patients were randomized 1:1 into two groups using concealed allocation. Due to the nature of interventions, clinicians were unblinded post-randomization.
Baseline data included age, gender, diagnosis, SOFA score, ventilation mode, hemodynamic, renal, and biochemical markers. In the clinical arm, physical signs such as capillary refill, edema, and jugular venous pressure were documented. Patients needing resuscitation received 20 ml/kg crystalloids, while fluid-overloaded cases received furosemide. In the ultrasound arm, IVC CI/DI was used to guide fluid or diuretic therapy, with reassessments done as needed.
Primary outcomes included 24h, day-7, and day-28 mortality, ΔSOFA (change from baseline to 24h), and cumulative fluid balance at 6h. Secondary outcomes were ICU stay duration, days on mechanical ventilation, and changes in pH, lactate (in sepsis), and blood sugar (in DKA) at 6h. Ancillary treatments such as vasopressors, steroids, and RRT were allowed at clinician discretion in both arms.
Data were analyzed using SPSS v23. Normality testing determined use of t-test or Mann-Whitney U test; Chi-square test was used for categorical variables. Significance was set at p<0.05.
Data showed significantly lower cumulative fluid balance in the IVC CI/DI group (1041.69 ml) vs. clinical group (1500.94 ml; p=0.04), though no subgroup differences were found. SOFA score changes were not significantly different, but hepatic and coagulation components approached significance (p=0.057). No difference was observed in ICU stay, ventilation days, or mortality at 24h and day 7. However, 28-day mortality was borderline significant (p=0.051), and Kaplan-Meier analysis showed improved survival in the IVC CI/DI group (p=0.046).

This dataset includes comprehensive clinical and biochemical data before and after fluid intervention, offering insights into early resuscitation responses in critically ill patients. It supports future analysis on fluid responsiveness, ultrasound utility, and personalized fluid therapy strategies in ICU settings.