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Total Synthesis of (−)-Pavidolide B: A Ring Contraction Strategy

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https://figshare.com/articles/dataset/Total_Synthesis_of_-Pavidolide_B_A_Ring_Contraction_Strategy/8344073
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A ring contraction approach for the total synthesis of (−)-pavidolide B was developed, which assembles this polycyclic natural product within 13 steps from known chiral alcohol 11. The key features of the strategy include (a) a double Mukaiyama–Michael addition/elimination, (b) a ring-closing metathesis, (c) a Wolff rearrangement, and (d) a late-stage regioselective Schenck ene reaction.
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2019-06-21
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