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Structure of porcine cyclic GMP AMP synthase (CGAS) in complex with DNA, ATP and GTP

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cGAS结构生物学

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Structure of porcine cyclic GMP AMP synthase (CGAS) in complex with DNA, ATP and GTP

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2023-09-20

蛋白质晶体

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Crystal structure of human cGAS apo form Descriptor: Cyclic GMP-AMP synthase, ZINC ION Authors: Kato, K, Ishii, R, Ishitani, R, Nureki, O. Deposit date: 2013-09-05 Release date: 2013-10-30 Last modifi

Protein Data Bank Japan2023-11-08 更新70

Gp130-dependent release of acute phase proteins is linked to the activation of innate immune signaling pathways

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细胞基因调控

Gp130 dependent gene expression was analyzed in a previously established hepatocyte-specific gp130-knockout mouse model. Whole transcriptome analysis for isolated hepatocytes was performed to measure

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The mechanism of STING autoinhibition and activation

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蛋白质结构与功能关系

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Mendeley Data40

Mechanisms Establishing TLR4-Responsive Activation States of Inflammatory Response Genes

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炎症与表观遗传调控

Precise control of the innate immune response is required for resistance to microbial infections and maintenance of normal tissue homeostasis. Because this response involves coordinate regulation of h

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Inherited human IRAK-1 deficiency selectively abolishes TLR signaling in fibroblasts

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免疫表型

We describe here a male infant with a 100 kb de novo Xq28 deletion encompassing parts of the TMEM187 and MECP2 protein-coding genes and the IRAK1 protein-coding gene, as well as the MIR3202-1, MIR3202

NIAID Data Ecosystem50

Structure of porcine cyclic GMP AMP synthase (CGAS) in complex with DNA, ATP and GTP

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