Crystal structure of nonphosphorylated, HPK1 kinase domain in complex with sunitinib in the inactive state.

Crystal structure of nonphosphorylated, HPK1 kinase domain in complex with sunitinib in the inactive state. Descriptor: Mitogen-activated protein kinase kinase kinase kinase 1, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide Authors: Johnson, E, McTigue, M, Cronin, C.N. Deposit date: 2018-12-21 Release date: 2019-05-01 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation. J.Biol.Chem., 294, 2019

非磷酸化且处于非活性状态、与舒尼替尼（sunitinib）结合的HPK1激酶结构域的晶体结构。描述项：丝裂原活化蛋白激酶激酶激酶激酶1（Mitogen-activated protein kinase kinase kinase kinase 1），N-[2-(二乙基氨基)乙基]-5-[(Z)-(5-氟-2-氧代-1,2-二氢-3H-吲哚-3-亚基)甲基]-2,4-二甲基-1H-吡咯-3-甲酰胺。作者：Johnson, E、McTigue, M、Cronin, C.N.。提交日期：2018-12-21。发布日期：2019-05-01。最后修订日期：2024-03-13。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.17埃（Å）。引用文献：《与舒尼替尼结合的HPK1激酶结构域的多种构象状态揭示了伴随HPK1反式调控的结构变化》，《生物化学杂志（J. Biol. Chem.）》，2019年，第294卷。