Additional file 1 of A phenome-wide association study of genetically mimicked statins

Additional file 1: Table S1. Established genetic variants in the HMGCR, PCSK9 and NCP1L1 gene that mimic statins, PCSK9 inhibitors and ezetimibe respectively]. Table S2. Correlation matrix for genetic variants mimicking statins. Table S3. Correlation matrix for genetic variants mimicking PCSK9 inhibitors. Table S4. Correlation matrix for genetic variants mimicking ezetimibe. Table S5. 56 established independent SNPs genetically predicting LDL-c. Table S6. PheWAS table of rs12916. Table S7. Number of significant associations of rs12916 with phenotypes by category. Table S8. Sex-specific associations of genetically mimicked statins, PCSK9 inhibitors and ezetimibe (based on rs12916, rs11591147 and rs10260606, respectively) with body composition traits. Table S9. Sex-specific univariable MR of genetically predicted LDL-c on binary traits and body composition traits. Table S10. Replication table. Table S11. Sensitivity analysis for genetically mimicking statins. Table S12. Sensitivity analysis for genetically mimicking PCSK9 inhibitors. Table S13. Sensitivity analysis for genetically mimicking ezetimibe. Table S14. Univariable MR results of BMI on platelet count and BMR. Table S15. Multivariable MR results of genetically mimicked statins on BMR adjusting for BMI.