Umbilical cord miRNA profile associated with catch-up growth in SGA infants. Umbilical cord miRNA profile associated with catch-up growth in SGA infants

The aim of this study was to identify umbilical cord microRNA (miRNA) associated with catch-up growth in SGA infants. miRCURY LNA™ Universal RT microRNA PCR Human Panel I+II (Exiqon) were used to study the miRNA profile in umbilical cord tissue of 5 SGA infants with catch-up (SGA-CU), 5 SGA infants without catch-up (SGA-nonCU) and 5 control infants (appropriate-for-gestational-age, AGA). Catch-up differentially expressed miRNA were studied and validated in a larger cohort. Overall design: qPCR gene expression profiling in umbilical cord from 15 subjects (5 SGA-CU, 5 SGA-nonCU and 5 AGA).