Global proteome analysis of protein glycosylation is a major challenge due to the inherent heterogeneous and diverse nature of this post-translational modification. It is therefore common to enzymatic
In our study, seven plasma proteomics methods were evaluated including five MS-based protocols (Neat (Untreated), TOP14 depletion (Thermo Scientific), Enrich (PreOmics, part of Bruker now), PCA-N (Man
C>T/G>A in the 1–10% VAF range of unfiltered NGS data are considered fixation artifacts. The best result is considered the lowest amount of artifacts of the same tissue.
Protein turnover is important for general health on cellular and organism scales providing a strategy to replace old, damaged, or dysfunctional proteins. Protein turnover also informs of biomarker kin
The development of ultrasensitive proteomic methods for the detection of proteins — potential tumor biomarkers — remains one of the key challenges in modern biomedicine. Based on data obtained using h
