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Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibition. Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibition

NIAID Data Ecosystem2026-05-01 收录

化疗耐药机制

信号通路

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1042820 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2023-11-19

化疗耐药机制

多组学整合分析

Continuous exposure to cisplatin can induce drug resistance to limit efficacy, however, the underlying mechanisms correlated to cisplatin resistance are still unclear. Drug-sensitive A549 cells and ci

NIAID Data Ecosystem70

Loss of IFN-g signaling in tumor cells associates with primary resistance to anti-CTLA-4 therapy

化疗耐药机制

IFN-γ信号通路

"Antibody blockade of the inhibitory CTLA-4 pathway has led to clinical benefit in a subset of patients with metastatic melanoma. Anti-CTLA-4 enhances T cell responses, including production of IFN-?,

NIAID Data Ecosystem40

Unveiling alterations of epigenetic modifications and chromatin architecture leading to lipid metabolic reprogramming during the evolutionary trastuzumab adaptation of HER2-positive breast cancer [Cut & Tag]. Unveiling alterations of epigenetic modifications and chromatin architecture leading to lipid metabolic reprogramming during the evolutionary trastuzumab adaptation of HER2-positive breast cancer [Cut & Tag]

化疗耐药机制

表观遗传调控

Secondary trastuzumab resistance represents an evolutionary adaptation of HER2-positive breast cancer during anti-HER2 treatment. Most current studies have uncovered the alternations of HER2 and assoc

NIAID Data Ecosystem20

Optimized parameter values for cAMP pathway full cAMP:SMN2 model.

信号通路

疾病靶点优化

The parameters marked with an asterisk (*) were carried over from the simplified cAMP model.Optimized parameter values for cAMP pathway full cAMP:SMN2 model.

Figshare2015-12-02 更新70

GO:0004706 (JUN kinase kinase kinase activity)

信号通路

激酶网络分析

This network was assembled automatically by INDRA (http://indra.bio) by processing all available biomedical literature with multiple machine reading systems, and integrating curated pathway databases.

NIAID Data Ecosystem30

Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibition. Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibition

资源简介：

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