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Massive reshaping of genome - nuclear lamina interactions during oncogene induced senescence

NIAID Data Ecosystem2026-03-11 收录

癌基因诱导衰老逃逸

核纤层-基因组相互作用

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE76605 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2020-01-06

核纤层-基因组相互作用

DamID技术

Specific interactions of the genome with the nuclear lamina (NL) are thought to assist chromosome folding inside the nucleus and to contribute to the regulation of gene expression. High-resolution map

NIAID Data Ecosystem30

Expression data from ER32 and ER32.40HT IMR90

癌基因诱导衰老逃逸

转录组图谱

IMR90 cells were infected with pLNC-RAS:ER (from Jesus Gil lab) with retroviral gene transfer. Infected cells were drug selected G418. The cells were induced either with ethanol as control or with 100

NIAID Data Ecosystem30

Unbiased identification of CSDE1-regulated targets during oncogene-induced senescence [RNA-Seq-sh]

癌基因诱导衰老逃逸

CSDE1靶基因鉴定

We show that the RNA-binding protein CSDE1/UNR promotes oncogene-induced senescence (OIS) in primary mouse keratynocytes challenged by over-expression of H-RASv12. Depletion of CSDE1 leads to senescen

NIAID Data Ecosystem20

Gene expression data from IMR90 Control, IMR90 HRAS-G12V, IMR90 HRAS-G12V+shDOT1L, IMR90 DOT1L Overexpression

癌基因诱导衰老逃逸

SASP转录调控

Oncogene-induced senescent cells display a robust change in their epigenome and have increased transcription and secretion of numerous pro-inflammatory cytokines and chemokines termed the senescence-a

NIAID Data Ecosystem30

Homo sapiens Transcriptome or Gene expression

癌基因诱导衰老逃逸

长链非编码RNA分析

investigation of lncRNAs deregulated in oncogenic induced senescence.

NIAID Data Ecosystem20