MOESM1 of Hemimethylation of CpG dyads is characteristic of secondary DMRs associated with imprinted loci and correlates with 5-hydroxymethylcytosine at paternally methylated sequences

Additional file 1. Methylation levels at imprinted DMRs generally do not vary across development. Mann–Whitney U tests were performed to compare methylation patterns on maternal and paternal alleles at each primary and secondary DMR across development. In general, methylation levels on each parental allele did not significantly change across development, illustrating that overall levels of methylation are maintained developmentally once they are established.