Catalytic Asymmetric Synthesis of Bicycloprolines by a 1,3-Dipolar Cycloaddition/Intramolecular Alkylation Strategy
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https://figshare.com/articles/dataset/Catalytic_Asymmetric_Synthesis_of_Bicycloprolines_by_a_1_3-Dipolar_Cycloaddition_Intramolecular_Alkylation_Strategy/3471104
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资源简介：
The diastereoselective one-pot synthesis
of hexahydrocyclopenta[b]pyrrole derivatives (bicycloprolines)
has been achieved
by base-mediated reactions of (E)-tert-butyl 6-bromo-2-hexenoate with α-imino esters. The catalytic
asymmetric version of this process has been efficiently achieved using
the CuI/(R)-DTBM-Segphos complex as a
catalyst following a two-step 1,3-dipolar cycloaddition/intramolecular
alkylation sequence.
创建时间：
2016-07-11
