Crystal structure of the 5-enolpyruvate-shikimate-3-phosphate synthase (EPSPS) domain of Aro1 from Candida albicans in complex with shikimate-3-phosphate

Crystal structure of the 5-enolpyruvate-shikimate-3-phosphate synthase (EPSPS) domain of Aro1 from Candida albicans in complex with shikimate-3-phosphate Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-enolpyruvylshikimate-3-phosphate synthase, SHIKIMATE-3-PHOSPHATE Authors: Stogios, P.J, Evdokimova, E, Michalska, K, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2021-12-22 Release date: 2022-03-16 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in Candida albicans. Life Sci Alliance, 5, 2022

白念珠菌（Candida albicans）来源Aro1蛋白的5-烯醇丙酮酰莽草酸-3-磷酸合酶（5-enolpyruvate-shikimate-3-phosphate synthase，EPSPS）结构域与莽草酸-3-磷酸形成复合物的晶体结构。配体描述：2-氨基-2-羟甲基-1,3-丙二醇、5-烯醇丙酮酰莽草酸-3-磷酸合酶、莽草酸-3-磷酸。作者：Stogios, P.J.、Evdokimova, E.、Michalska, K.、Di Leo, R.、Savchenko, A.、Joachimiak, A.、Satchell, K.J.F.；传染病结构基因组学中心（Center for Structural Genomics of Infectious Diseases, CSGID）。提交日期：2021-12-22；发布日期：2022-03-16；最后修改日期：2023-10-25。实验方法：X射线衍射（1.85埃）。引用文献：《白念珠菌Aro1莽草酸生物合成多酶的分子分析与必需性研究》，《生命科学联盟》，第5卷，2022年。