Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ384 (compound 4a)
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Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ384 (compound 4a) Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-azanylidene-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', ... Authors: Maskell, D.P, Pye, V.E, Cherepanov, P. Deposit date: 2015-12-18 Release date: 2016-02-17 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.58 Å) Cite: HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases. Acs Chem.Biol., 11, 2016
原型泡沫病毒（Prototype Foamy Virus, PFV）整合体与镁离子及整合酶链转移抑制剂（Integrase Strand Transfer Inhibitor, INSTI）XZ384（化合物4a）的共晶结构
描述：2-(N-吗啉代)乙磺酸，4-亚氨基-N-[[2,4-二氟苯基]甲基]-1-羟基-2-氧代-1,8-萘啶-3-甲酰胺，5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'，……
作者：Maskell, D.P, Pye, V.E, Cherepanov, P.
提交日期：2015-12-18
发布日期：2016-02-17
最后修改日期：2024-01-10
实验方法：X射线衍射（2.58 Å）
引用文献：《对耐药突变整合酶敏感性降低的HIV-1整合酶链转移抑制剂》，Acs Chem.Biol., 11, 2016
创建时间：
2015-12-18
