Incidence of adverse reactions in general population treated with benzathine penicillin: individual and pooled results, 1954–2012.

Notes:
*Only severe adverse reaction was reported.
†Probable cases.
‡These cases are included in the previous data (one penicillin prescription).
§Data obtained from contact with corresponding author.
||The study reported 16 events of Jarisch-Herxheimer reaction, but we did not consider them as adverse events.
¶For the polled result only the incidence of adverse reaction with one prescription of penicillin was considered for Apter 2004 [95] study.