T-cell acute lymphobalstic leukemia xenografts in NOD/SCID mouse

Gene expression analysis of twenty patient-derived T-ALL xenografts was performed to determine if a GLI activation signature was enriched in GANT-61 sensitive cells. Gene expression analysis of twenty patient-derived T-ALL xenografts using cells obtained from the spleens of diseased mice. Cells obtained from independent mice were evaluated in vitro for their sensitivity to the GLI inhibitor, GANT-61.