Hazard ratios or relative change ratios for bucindolol/placebo (95% confidence intervals), number of events, and log-rank P values for clinical endpoints and norepinephrine change by genotype combination groups.

Abbreviations: ACM, all-cause mortality; B, bucindolol; CI, confidence interval; CVH, cardiovascular hospitalization; CVM, cardiovascular mortality; HFH, heart failure hospitalization; HFP, heart failure progression (composite of heart failure death, cardiac transplantation, heart failure hospitalization, or an emergency department visit for treatment of heart failure involving administration of intravenous heart failure medication); HR, hazard ratio; P, placebo; NE, norepinephrine; RCR, relative change ratio; RES, relative effect size.ANumber of events presented are using the unadjusted analysis, which differs slightly from covariate-adjusted because adjusted analyses are transplant-censored.BAll genotypes.Cβ1389 Arg/Arg+α2C Wt/Wt.Dβ1389 Arg/Arg+α2C Del carrier.Eβ1389 Arg/Arg+any α2C.Fβ1389 Gly carrier+α2C Wt/Wt.Gβ1389 Gly carrier+α2C Del carrier.HInteraction P value≤0.20, >0.10.IInteraction P value≤0.10, >0.05.JRelative change ratio.K[1−HR or RCR]×100.LRES = Ln HR (genotype group)/Ln (DNA substudy cohort).MSee Methods.