Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' cGAMP, c[G(3', 5')pA(3', 5')p]

Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' cGAMP, c[G(3', 5')pA(3', 5')p] Descriptor: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, CITRATE ANION, Stimulator of Interferon Genes Authors: Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E. Deposit date: 2015-07-08 Release date: 2015-08-26 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.994 Å) Cite: Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol.Cell, 59, 2015

星海葵（Nematostella vectensis）STING（干扰素基因刺激因子，Stimulator of Interferon Genes）与3',3'-cGAMP（c[G(3',5')pA(3',5')p]）结合的晶体结构
描述符: 2-氨基-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-氨基-9H-嘌呤-9-基)-3,5,10,12-四羟基-5,12-二氧代八氢-2H,7H-二呋喃并[3,2-d:3',2'-j][1,3,7,9,2,8]四氧杂二磷杂环十二烷-2-基]-1,9-二氢-6H-嘌呤-6-酮、柠檬酸根阴离子、干扰素基因刺激因子（Stimulator of Interferon Genes）
作者: Kranzusch, P.J.、Wilson, S.C.、Lee, A.S.Y.、Berger, J.M.、Doudna, J.A.、Vance, R.E.
沉积日期: 2015-07-08
发布日期: 2015-08-26
最后修改日期: 2024-03-06
检测方法: X射线衍射（分辨率1.994 Å）
引用: 《cGAS-STING通路的古老起源揭示通用2',3'-cGAMP信号转导机制》，Mol.Cell, 59, 2015