Synthesis of Azepinoindoles via Rhodium-Catalyzed Formal Aza-[4 + 3] Cycloaddition Reaction of 3‑Diazoindolin-2-imines with 1,3-Dienes in One-Pot
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Rhodium-catalyzed formal aza-[4 + 3] cycloaddition reaction of 3-diazoindolin-2-imines with 1,3-dienes was demonstrated for the synthesis of azepinoindoles in good to excellent yields in one-pot. First, rhodium-catalyzed [2 + 1] cycloaddition reaction smoothly took place to produce iminyl vinyl cyclopropane intermediate at room temperature in chlorobenzene for 1 h, which was thermally converted to azepinoindoles via aza-Cope rearrangement.
创建时间：
2017-08-28
