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Crystal structure of human DNPH1 bound to inhibitor 2b

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Protein Data Bank Japan2025-02-26 更新2026-08-24 收录
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Crystal structure of human DNPH1 bound to inhibitor 2b Descriptor: 5-hydroxymethyl-dUMP N-hydrolase, {(3R,4R)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-hydroxypyrrolidin-3-yl}methyl dihydrogen phosphate Authors: Wagner, A.G, Schramm, V.L, Almo, S.C, Ghosh, A. Deposit date: 2024-08-21 Release date: 2025-02-05 Last modified: 2025-02-26 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Transition State Analogs of Human DNPH1 Reveal Two Electrophile Migration Mechanisms. J.Med.Chem., 68, 2025

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2024-08-21
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