Crystal structure of the Fucosylgalactoside alpha N- acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with NPE caged UDP-Gal (C222(1) space group)

Crystal structure of the Fucosylgalactoside alpha N- acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with NPE caged UDP-Gal (C222(1) space group) Descriptor: 1-(2-NITROPHENYL)ETHYL UDP-GALACTOSE, GLYCEROL, HISTO-BLOOD GROUP ABO SYSTEM TRANSFERASE, ... Authors: Jorgensen, R, Batot, G.O, Hindsgaul, O, Tanaka, H, Perez, S, Imberty, A, Breton, C, Royant, A, Palcic, M.M. Deposit date: 2012-12-17 Release date: 2014-01-15 Last modified: 2026-04-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structures of a Human Blood Group Glycosyltransferase in Complex with a Photo-Activatable Udp-Gal Derivative Reveal Two Different Binding Conformations Acta Crystallogr.,Sect.F, 70, 2014

该数据集为岩藻糖基半乳糖苷α-N-乙酰半乳糖胺基转移酶（Fucosylgalactoside alpha N-acetylgalactosaminyltransferase，简称GTA，cisAB突变体L266G、G268A）与2-硝基苯乙基（NPE）笼型UDP-半乳糖（UDP-Gal）形成的复合物晶体结构，所属空间群为C222₁。
配体描述：1-(2-硝基苯基)乙基UDP-半乳糖、甘油、组织血型ABO系统转移酶等。
作者：Jorgensen R、Batot G.O、Hindsgaul O、Tanaka H、Perez S、Imberty A、Breton C、Royant A、Palcic M.M.
提交日期：2012-12-17
发布日期：2014-01-15
最后修改日期：2026-04-15
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.9 Å
引用文献：《人血型糖基转移酶与光活化UDP-半乳糖衍生物复合物的结构揭示两种不同结合构象》，发表于《Acta Crystallographica Section F》2014年第70卷。