Structure of BasE N-terminal domain from Acinetobacter baumannii bound to 6-(p-benzyloxy)phenyl-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid.

Structure of BasE N-terminal domain from Acinetobacter baumannii bound to 6-(p-benzyloxy)phenyl-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid. Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 6-[4-(benzyloxy)phenyl]-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid, ... Authors: Gulick, A.M, Drake, E.J, Aldrich, C.C, Neres, J. Deposit date: 2011-09-29 Release date: 2012-10-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii. J.Med.Chem., 56, 2013

鲍曼不动杆菌（Acinetobacter baumannii）BasE蛋白N端结构域与6-(对苄氧基苯基)-1-(吡啶-4-基甲基)-1H-吡唑并[3,4-b]吡啶-4-羧酸的结合晶体结构。配体信息：(4R)-2-甲基戊烷-2,4-二醇、(4S)-2-甲基-2,4-戊二醇、6-[4-(苄氧基)苯基]-1-(吡啶-4-基甲基)-1H-吡唑并[3,4-b]吡啶-4-羧酸等。作者：Gulick, A.M.、Drake, E.J.、Aldrich, C.C.、Neres, J.。存档日期：2011年9月29日；发布日期：2012年10月3日；最后修改日期：2023年9月13日。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.1 Å）。引用文献：《靶向机会性病原体鲍曼不动杆菌铁载体（siderophore）生物合成途径中腺苷酸化酶BasE的非核苷类抑制剂》，J.Med.Chem., 56, 2013