Inhalation exposure of hexanal in rats (DNA methylation)
收藏NIAID Data Ecosystem2026-03-12 收录
下载链接：
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE129313
下载链接
链接失效反馈官方服务：
资源简介：
To further development of insight into the mechanism of toxicity, it is important to employ whole genome microarray expression profiling to identify and characterize DNA methylation profiles as a discovery platform relevant for toxicologic mechanisms of hexanal. DNA methylation have prominent epigenetic role in regulation of gene expression, cell cycle control, apoptosis, cancer development and proliferation-related processes. However, few reports have described the effect of hexanal on DNA methylation expression profiles using animal model. In this respect, we studied the expression profiles of DNA methylation in hexanal-exposed in rats by DNA methylation microarray analysis. To evaluate the DNA methylation expression in lung tissue of rats after exposure of hexanal, Fischer-344 rats were inhaled to three concentrations (600, 1000, 1500 mg/m3) for 5 weeks. DNA methylation expression analysis was conducted using custom-designed 400K methylation microarray (Agilent Technologies, USA).
创建时间：
2021-02-23
