Seasonal genes and their associated binomial P value.

For each season and seasonal gene, the number of tissues for which the gene is up- or down-regulated, for (i) all tissues, (ii) non-brain tissues, and (iii) brain tissues. For each of the previous tissue classification, a binomial P value is associated to test if the gene has a statistically significant preference to be up- or down-regulated in that season. Genes with a P ≤ 0.05 for one of the tissue classifications are part of the high-confidence seasonal gene sets. Note that for a gene to reach a P ≤ 0.05, it needs to have been identified as differentially expressed in that season in at least 6 tissues. See Methods for details. (XLSX)