Diethanolamine Boronic Esters: Development of a Simple and Standard Process for Boronic Ester Synthesis
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https://figshare.com/articles/dataset/Diethanolamine_Boronic_Esters_Development_of_a_Simple_and_Standard_Process_for_Boronic_Ester_Synthesis/12818604
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资源简介：
Herein, we disclose the unique physical
properties of diethanolamine
(DEA) boronic esters that have facilitated the development of a simple
and standard process for their synthesis and isolation using environmentally
sustainable solvents. Moreover, their preparation is facile, robust,
and scalable and can be telescoped from a solution of boronic acid
or boronic ester via esterification/transesterification
with DEA, therefore providing wide access from a plethora of reaction
types. To date, AstraZeneca has successfully manufactured three DEA
boronic esters at the kilogram scale (5, 50, and 100 kg batches),
with plans to expand this to more examples in 2020.
创建时间：
2020-08-04
