Boosting ATM activity alleviates ageing and extends lifespan in a mouse model of progeria.

Protein deacetylase SIRT6 and protein kinase ATM both decline during aging, which are of importance in regualtion of glucose metabolism . To explore the mechnisms of SIRT6 and ATM in glycolysis, we analysed the gene expressions in murine embryonic fibroblast cells generated from wildtype, Sirt6-/-, or Atm-/- mice. Overall design: The mRNA profiles of MEF cells from wildtype, Sirt6-/-, or Atm-/- not were generated by deep sequencing using Illumina HiSeq x ten