Environmental interactions and epistasis are revealed in the proteomic responses to complex stimuli

Data from ProteomeXchange, PXD ID: PXD002371. File: WYPG37C_iTRAQ_11Step-MudPIT_21Jan12_PD1.4.msf.mgf. From ProteomeXchange: {{i}} ... In this study, we developed the concepts of environmental interactions and epistasis to explain the responses of the S. cerevisiae proteome to simultaneous environmental stimuli. We hypothesize that, as an abstraction, environmental stimuli can be treated as analogous to genetic elements. This would allow modeling of the effects of multiple stimuli using the concepts and tools developed for studying gene interactions. Mirroring gene interactions, our results show that environmental interactions play a critical role in determining the state of the proteome. We show that individual and complex environmental stimuli behave similarly to genetic elements in regulating the cellular responses to stimuli, including the phenomena of dominance and suppression ... {{/i}}