Evolutionary origin of Group 3/4 medulloblastoma

This repository contains variant calls from bulk whole genome sequencing of medulloblastomas that were first published in Northcott, P. A. et al. The whole-genome landscape of medulloblastoma subtypes. Nature 547, 311-317 (2017); https://doi.org/10.1038/nature22973 and re-analyzed for reconstructing evolutionary dynamics driving medulloblastoma initiation in the manuscript

Key oncogenic event are late-stage drivers of medulloblastoma evolution and progression

Konstantin Okonechnikov1,2,3*, Piyush Joshi1,2,3,4*, Verena Körber5,6*, et al.

1. Hopp Children’s Cancer Center (KiTZ), Heidelberg, Germany
2. National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany
3. Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany
4. Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
5. Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany
6. MRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, UK

* these authors contributed equally

The repository additionally contains reference data used for the analysis in Okonechnikov, Joshi & Körber et al.