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A designed ankyrin repeat protein evolved to picomolar affinity to Her2

NIAID Data Ecosystem2026-05-01 收录

蛋白质定向进化

Her2靶向亲和力

数据链接：

https://www.rcsb.org/structure/2JAB 数据链接链接失效反馈

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A designed ankyrin repeat protein evolved to picomolar affinity to Her2

应用场景：

创建时间：

2023-12-13

蛋白质定向进化

合成生物文库设计

CDR’ refers to a degenerate codon with the following nucleotide frequencies: 20% A, 15% C, 25% G, and 40% T at site 1, 50% A, 25% C, 15% G, and 10% T at site 2, and 0% A, 45% C, 10% G, and 45% T at si

NIAID Data Ecosystem30

Table1_Binding pocket stabilization by high-throughput screening of yeast display libraries.DOCX

蛋白质定向进化

高通量药物筛选

Protein dynamics have a great influence on the binding pockets of some therapeutic targets. Flexible protein binding sites can result in transient binding pocket formation which might have a negative

NIAID Data Ecosystem10

Improved activity and stability of Klebsiella pneumoniae-derived 1,3-propanediol dehydrogenase

酶工程

蛋白质定向进化

1,3-propanediol dehydrogenase mutant with improved activity and stability after targeted mutagenesis by computer-aided design of mutation sites

NIAID Data Ecosystem10

Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 17 round 7-2

蛋白质定向进化

晶体结构解析

Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 17 round 7-2

NIAID Data Ecosystem20

Lucilia cuprina alpha esterase 7 directed evolution round 8

蛋白质定向进化

昆虫抗药性

Lucilia cuprina alpha esterase 7 directed evolution round 8 Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, ACETATE ION, ... Authors: Frkic, R.L, Fraser, N, Mabbitt, P.D, Jackson, C.J. Depo

Protein Data Bank Japan2026-03-04 更新10

A designed ankyrin repeat protein evolved to picomolar affinity to Her2

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