MYH6 gene promoter in isolated ventricular septal defects

This study enrolled 604 subjects. A total of 464 Chinese patients with isolated and sporadic VSD underwent repair surgery from January 2018 to August 2019 at the Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin, China. A total of 311 VSD patients (167 males and 144 females; age range: 1 month to 12 years) were enrolled in this study. The exclusion criteria were patients without blood samples, or with a family history of CHD, or with other comorbid hereditary disorders. The blood samples from those patients were collected. In addition, blood samples from 293 healthy controls (166 males and 127 females; age range: 1 month to 12 years) were also collected.