Long-term effects of adolescent EtOH binge drinking after cocaine withdrawal in adulthood on elevated plus maze: PND 80.

Over PND 34–47 (adolescence) mice (n = 10 per group) were pretreated with Sal or EtOH (1.25 g/kg administered 16 times in two daily i.p. injections separated by a 4-h interval on two consecutive days followed by a 48-h “drug-free” period). In adulthood (21 days later) they were treated with Sal or Coca in three daily i.p. injections separated by a 60-min interval according to the following regime: 5 mg/kg on PND 68 and 69, 15 mg/kg from PND 70 to 72, a 2-day abstinence period, and 25 mg/kg from PND 75 to 79 (** pp