Crystal Structure of the bromodomain of human BRD9 in complex with the inhibitor Y22032

Crystal Structure of the bromodomain of human BRD9 in complex with the inhibitor Y22032 Descriptor: 1-[1-[2,5-dimethoxy-4-[(1~{S})-1-oxidanylethyl]phenyl]indolizin-3-yl]ethanone, Bromodomain-containing protein 9 Authors: Chen, Z, Zhang, C, Xu, H, Wu, X, Zhang, Y, Xu, Y. Deposit date: 2024-11-15 Release date: 2025-11-05 Last modified: 2026-01-14 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Key imidazolyl groups that induce phenylalanine flipping enhance the efficacy of oral BRD9 inhibitors for AML treatment. Acta Pharm Sin B, 15, 2025