Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine-sulfonamide inhibitor
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Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine-sulfonamide inhibitor Descriptor: N-(5-{[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl]amino}-2-chloropyridin-3-yl)methanesulfonamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION Authors: Whittington, D.A, Tang, J, Yakowec, P. Deposit date: 2012-05-07 Release date: 2012-08-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3 Å) Cite: Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold. Bioorg.Med.Chem.Lett., 22, 2012
人源磷脂酰肌醇3-激酶γ（PI3K-γ）与吡啶基-三嗪-磺酰胺类抑制剂复合物的晶体结构
描述物：N-(5-{[3-(4-氨基-6-甲基-1,3,5-三嗪-2-基)-5-(四氢-2H-吡喃-4-基)吡啶-2-基]氨基}-2-氯吡啶-3-基)甲磺酰胺、磷脂酰肌醇4,5-二磷酸3-激酶催化亚基γ亚型、硫酸根离子
作者：Whittington, D.A、Tang, J、Yakowec, P.
入库日期：2012-05-07
发布日期：2012-08-08
最后修改日期：2024-02-28
实验方法：X射线衍射（分辨率3 Å）
引用文献：基于4-氨基-6-甲基-1,3,5-三嗪磺酰胺骨架的双靶点PI3K/mTOR抑制剂的合成及其构效关系研究，《Bioorg.Med.Chem.Lett.》，22卷，2012年
创建时间：
2012-05-07
