Amino acid conjugation

Xenobiotic compounds containing a carboxylic acid group (-COOH) or an aromatic hydroxylamine (-NHOH) group can be substrates for amino acid conjugation. (Source: http://reactome.org/content/detail/R-HSA-156587) Amino acid conjugation is important in the biotransformation of several xenobiotic carboxylic acids. An amide or peptide bond can be formed between the carboxyl group of the xenobiotic and the amino group of an amino acid, mainly glycine, taurine or glutamine. (Source: Hutt A.J., Caldwell J. Conjugation Reactions In Drug Metabolism; Chapter 10 Amino acid conjugation; 1990).

含有羧基团(-COOH)或芳香羟胺团(-NHOH)的异生物化合物，可作为氨基酸结合的底物。氨基酸结合在多种异生物羧酸的生物转化过程中扮演着重要角色。异生物的羧基与氨基酸的氨基之间可以形成酰胺或肽键，主要涉及甘氨酸、牛磺酸或谷氨酰胺等氨基酸。（来源：http://reactome.org/content/detail/R-HSA-156587；Hutt A.J., Caldwell J. 《药物代谢中的结合反应》；第10章 氨基酸结合；1990年）。