Associations between LIN28 genotypes and breast cancer risk in the test set.

The significance of boldface is a P-value of <0.05.
*Unadjusted odds ratio (OR) and 95% confidential interval (CI) calculated by logistic regression.
†OR and 95% CI calculated by logistic regression, adjusted for age, age at menarche, menopause status, number of birth, body mass index (BMI) and family history of breast cancer. Major genotype is indicated as reference.
‡For the model, homozygotes for the major allele (1/1), heterozygotes (1/2), and homozygotes for the rare allele (2/2) are coded as a continuous numeric variable for genotype (i.e. 0, 1, and 2). The dominant model is defined as contrasting genotypic groups 1/1 versus (1/2+2/2), and the recessive model is defined as contrasting genotypic groups 2/2 versus (1/1+1/2).